Type 2 Diabetes Mellitus (T2DM) is one of the world’s fastest growing chronic illness. Diabetic foot disease (DFD) remains one of the most severe complications in people with diabetes, contributed by anatomical foot deformities, peripheral neuropathy and vascular disease which impair wound healing. The field exploring the relationship between gut dysbiosis, T2DM and its complications is a growing one, with several studies reporting gut microbiome dysbiosis as a factor in the progression of insulin resistance in T2DM. Till date, there have only been a handful of human observation studies exploring this relationship. Current research is still in its early stages with a general lack of consensus on pathognomonic bacteria. In general, T2DM has been associated with changes in the balance of gut rather than the action of a single microbe or simple enhancement in diversity. There is also limited evidence on the impact of dysbiosis on the complications of T2DM such as diabetic foot disease. The purpose of this study is to summarise current evidence of gut dysbiosis for T2DM, the role and mechanisms involved in the pathophysiology of T2DM and the potential impact it has on DFD.